While ER004 did not lead to any major or significant side effects, it did not work on improving XLHED symptoms.
We now understand that replacing the missing EDA protein with ER004 after birth came too late as the development of the structures had already occurred.
Therefore, for the replacement ER004 to have a chance to work, it must be given during the development of the important structures (sweat glands, hair, teeth etc.), before birth.
We believe ER004 does not cross to the pregnant woman and you should therefore expect no benefits for your own health. During the treatment period, and up until 1 month after your baby’s birth, your health will be closely monitored alongside that of your baby.
Giving ER004 to your baby while still in the womb might sound scary. However, we think this is the only time at which the treatment might work.